Biological effects of melatonin on telomere length in breast cancer: a review article
نویسندگان
چکیده
There has been increasing interest in studying the effects of dietary factors on telomere length. The is a noncoding DNA sequence including "TTAGGG" at ends chromosomes vertebrates. stability length an important factor as survival signal for cells and cancer prevention. Telomerase multi-subunit polymerase that plays crucial role maintaining length, which critical age-related pathogenesis breast neoplasm. Some regulatory interfere with telomerase activity therefore promote tumorigenesis. High restoring lengths are determined key progressing tumors to advanced stages malignancies, highly estrogen-dependent carcinogenesis. Melatonin hormone-like substance secreted by pineal gland reported downregulate telomerase. It may control cells. Certain malignancy-related biological pathways have recently linked this review provides new insights regarding melatonin reviewing anticarcinogenic mechanisms underlying relation Experimental presenting alone or combination drugs enhancing therapeutic protocols were also reviewed, could assist our understanding telomeres prognostic biomarkers cancer.
منابع مشابه
Telomere Length and Breast Cancer Prognosis: A Systematic Review.
Telomeres ensure genome integrity during replication. Loss of telomeric function leads to cell immortalization and accumulation of genetic alterations. The association of telomere length (TL) with breast cancer prognosis is examined through a systematic review. Electronic databases (MEDLINE, EMBASE, CENTRAL), from inception to December 2015, and relevant reviews were searched. Studies that eval...
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ژورنال
عنوان ژورنال: Pharmaceutical Sciences
سال: 2022
ISSN: ['2383-2886']
DOI: https://doi.org/10.34172/ps.2022.46